Rebel Wilson lost 80 lbs. in 2020, dubbing it her “year of health.”
The “Pitch Perfect” star was 39 going on 40, and told her doctor she wanted to pursue in-vitro fertilization (IVF) and freeze her eggs.
The doctor looked her up and down and told her, “You’re really unhealthy. You’d have a much better chance if you were healthy.”
“It was a kick in the stomach kind of thing,” Wilson, now 45, says. “I didn’t have any serious disease. But if I kept going at the rate I was, maybe I would have.”
Wilson was diagnosed with polycystic ovarian syndrome (PCOS) at 21 and prescribed birth control pills to manage her symptoms. Her doctors never mentioned that losing weight could help alleviate them.
“That almost cost me two decades of health,” she says. “It made it nearly impossible with PCOS and the birth control pills to ever lose weight. My hormones were so out of whack.”
PCOS is also a leading cause of infertility in women, but some clinics won’t perform egg retrievals on patients unless they’re below a certain BMI.
And while wanting a baby was the initial inspiration, Wilson says her love life — or lack thereof — played a role.
“I was totally single. I don’t think that was necessarily because of my size; it was because of how I felt about myself,” she shares. “And so, getting healthy weirdly correlated to me feeling better about myself, which then translated into a much better love life.”
On Sept. 18, Wilson was announced as the Chief Wellness Ambassador at Noom, a virtual platform for weight loss and preventative health. Wilson is the face of their new campaign for “daily microhabits,” which can include achieving a daily step goal or eating a healthy snack, as well as “microdosing” GLP-1s.
GLP-1 ‘microdosing’ is becoming popular. Even Rebel Wilson does it.
The explosion of interest in weight-loss medication from brands like Ozempic, Wegovy and Mounjaro over the past few years has transformed the medical and pharmaceutical landscape.
Wilson says she focused solely on getting healthier in 2020. She exercised daily for over two hours and followed a high-protein diet. But looking back, she wishes she had known about GLP-1s then.
She found out about the weight loss drugs from her “celebrity OBGYN,” who said that many other actresses were on them.
“She’d seen my transformation, and she was like, ‘It’s going to be really hard for you to keep that up,’” Wilson recalls. Her doctor said excessive exercise wasn’t realistic — just one injury could disrupt her progress.
Wilson explored GLP-1 microdosing — going on and off low doses of the medication for periods of two months at a time. Leading up to her wedding to Ramona Agruma in Sept. 2024, Wilson used Noom’s 10-week GLP-1 program, taking a higher dose to “drop a few pounds” for her wedding dress.
“I felt amazing, I looked amazing,” she says. But, for now, she’s back to microdosing while “playing a funny character in a movie.”
“I don’t necessarily care about my weight right now,” she adds.
Under the “extreme pressure and stress” of working 12 to 13 hours a day, all while being a mom to her 2-year-old daughter, Royce, Wilson says microdosing helps stabilize her weight.
As with any prescribed medicine, weight-loss drugs should only be taken under the recommendation and supervision of a doctor. Do not microdose them unless your doctor tells you to, and follow their instructions closely.
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Rebel Wilson talks GLP-1 craze, ‘microdosing’ and why she lost weight
