Hydrophobic remodeling of the SARS-CoV-2 RBD large loop attenuates ACE2 engagement and viral fitness

?
This is an uncorrected proof.
Figures
Abstract
The SARS-CoV-2 Omicron subvariant JN.4 harbors a unique A475V substitution within the receptor binding domain (RBD) but exhibits limited expansion compared to its parallel descendant JN.1. Here, we inv… [65008 chars]